Synthesis, antitumor evaluation and molecular modeling study of novel benzimidazoles and pyrazinobenzimidazoles
نویسندگان
چکیده
Ahmed A. B. Mohamed, Farid A. Badria, Azza R. Maarouf, Naglaa I. Abdel-Aziz, Fardous ElSenduny, Alaa A.M. Abdel-Aziz, Said M. Bayomi Department of Medicinal Chemistry, Faculty of Pharmacy, University of Mansoura, Mansoura 35516, Egypt. Department of Pharmacognosy, Faculty of Pharmacy, University of Mansoura, Mansoura 35516, Egypt. Department of Biochemistry, Faculty of Science, University of Mansoura, Mansoura, Egypt. Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia.
منابع مشابه
Design, Synthesis, Biological Evaluation and Molecular Modeling Study of Novel Indolizine-1-Carbonitrile Derivatives as Potential Anti-Microbial Agents
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A novel one-pot two step tandem reaction for the synthesis of indolizine-1-carbonitrile derivatives (5a-i) was identified. The route comprises 1,3-dipolar cycloaddition reaction of aromatic aldehyde derivatives (1a-i), malononitrile (2) and 1-(2-(4-bromophenyl)-2-oxoethyl)-2-chloropyridin-1-ium (4) under ultrasound irradiation at room temperature in the presence of triethylamine at acetonitrile...
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